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Wednesday, February 11, 2009

UT Southwestern performs first local implant in deep brain stimulation study for depression

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UT Southwestern Medical Center neurological surgeons have begun implanting patients as part of a clinical study that is investigating whether deep brain stimulation (DBS) therapy may help people who suffer from major depressive disorder, a severe form of depression.

The implants are nigh-invisible to the naked eye

Photo not provided by UT Southwestern

The implants are nigh-invisible to the naked eye

The BROADEN (BROdmann Area 25 DEep brain Neuromodulation) study is a controlled, multi-site, blinded, clinical study that is evaluating the safety and effectiveness of DBS therapy in patients with depression for whom currently available treatments are not effective. UT Southwestern is one of three U.S. sites currently participating in this clinical study.

The Libra DBS system being evaluated in this study is designed to provide mild pulses of current to a part of the brain called Brodmann Area 25. This area appears to be overactive when people are profoundly depressed.

“Studies such as this are an important step in the development of new therapies. Treatment-resistant patients are those who have tried numerous medications to treat their depression. They feel hopeless and over many years, their quality of life has deteriorated,” said Mustafa Husain, M.D., professor of psychiatry and internal medicine at UT Southwestern and director of the UT Southwestern Neurostimulation Research Lab. “We are optimistic that this research will lead to a therapy that can provide these patients with some much-needed hope.”

In the U.S., more than 21 million adults suffer from some kind of depressive disorder, according to the National Institute of Mental Health. Of these, only about 80 percent can be effectively treated with currently available therapies, according to the National Advisory Mental Health Council. That means approximately 4 million adult Americans live with depression that doesn’t respond to medications or psychotherapy.

“The Libra DBS system’s generator or ‘battery’ is implanted near the collarbone and connected to small electrical leads placed at specific targets in the brain,” said Tony Whitworth, M.D., assistant professor of neurological surgery at UT Southwestern, who performed the implants. “The implantation surgery takes about two to three hours. Patients typically are able to go home one or two days after the procedure.”

Source: UT Southwestern


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